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Combined dietary and pharmacological weight management in obese hypopituitary patients.OBJECTIVE. Absolute amount of body weight lost was similar in Caucasians (-5.4 /- 3.6 kg)

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lap band weight loss allocated to 11-month treatment with Sibutramine ( Meridia ) (10 to

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15 mg), diet (600 kcal/d deficit),

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and exercise. Only baseline weight and waist circumference could predict weight loss (with or without diet pills) at 11 months. Mean ( /-SD) weight loss (with or without diet pills) at 11 months was 11.3 /- 4.8 kg in patients vs. Almost all will achieve at least 5% weight loss (with or without diet pills), and 60% can lose >10% zonisamide and weight loss

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weight within 11 months. However, the long-term effect on risk factors associated with type 2 diabetes and cardiovascular

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disease as well as on mortality needs to be established. There are few empirical data to support

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the claim that weight loss (with or without diet pills) improves coronary

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heart disease (CHD) risk factors in postmenopausal women; nor is it known if there are racial differences

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in changes of body fat distribution, lipids, glucose tolerance, and blood pressure with weight loss (with or without diet pills). RESEARCH METHODS AND PROCEDURES. In a multivariate model, baseline weight, duration of growth hormone replacement therapy, and duration of

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pituitary disease explained 79% (p 0.001) of the variation in weight loss (with or without diet pills) at 4 months in the HPs. In this study, we investigated the combined effect of Sibutramine ( Meridia ), diet, and exercise in obese hypopituitary

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patients (HPs). This study determined the efficacy of a lifestyle weight loss (with or without diet pills) intervention in reducing total and abdominal obesity and improving CHD risk factors in obese Caucasian and African-American postmenopausal women. Anthropometric indices and body composition (obtained from DXA scan) were assessed monthly for the first 5 months and thereafter every second month for the next 6 months. HPs are not resistant to weight loss (with or without diet pills) therapy. Lifestyle intervention of hypocaloric dieting and walking reduces abdominal obesity and improves coronary heart disease risk factors in obese, postmenopausal, African-American and Caucasian women.BACKGROUND. The high prevalence of obesity and cardiovascular risk factors in hypopituitarism affirms the need for effective weight loss (with or without diet pills) intervention. Body composition (dual-energy x-ray absorptiometry), abdominal fat areas (computed tomography scan), lipoprotein lipids, insulin, glucose tolerance, and blood pressure were measured before and after 6 months of hypocaloric diet and low-intensity walking in 76 overweight or obese (body mass index >

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25 kg/m(2)), Caucasian (72%) or African-American (28%), postmenopausal (age 60 /- 5 years) women who completed the study.

The HPs exhibited the same improvements in body composition, waist circumference, blood lipids, and fasting glucose as the simple obese.